Manjiro encounters Ryoan walking home after a night on the town and he tells Manjiro about his impending arranged marriage to Otsune. Later, the two young men are told that Harris has demanded to see the Shogun Iesada Tokugawa in Edo, but the shogun is not fit to receive him. The court physicians are given a month to cure him and they have secretly asked the western doctors to help because they fear they cannot heal him...